Criteria to observe mesoscopic emergence of protein biophysical properties

Article summary of Criteria to observe mesoscopic emergence of protein biophysical properties

Proteins range in size from tens to tens of thousands of residues (TRP-Cage to Titin), with each individual atom known.  When these proteins are folded, physical surface macro properties such as hydrophobicity and polarity emerge.  This article abstractly attempts to set up a framework (a control theoretic construct) for stating how many atoms (or amino acids) are needed before an emergent property can be observed.

The article sites many references.  New to me is that it is an interesting open issue that a bottom up approach to determining hydrphobicity and polarity has yet to be found.  I did not yet find out what a control theoretic construct is.

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